7K2Y
Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed ampicillin
Summary for 7K2Y
Entry DOI | 10.2210/pdb7k2y/pdb |
Descriptor | Beta-lactamase, (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (3 entities in total) |
Functional Keywords | antibiotic resistance, acyl-enzyme intermediate, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28080.66 |
Authors | Lu, S.,Palzkill, T.,Sankaran, B.,Hu, L.,Soeung, V.,Prasad, B.V.V. (deposition date: 2020-09-09, release date: 2020-11-04, Last modification date: 2023-10-18) |
Primary citation | Soeung, V.,Lu, S.,Hu, L.,Judge, A.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J.Biol.Chem., 295:18239-18255, 2020 Cited by PubMed: 33109613DOI: 10.1074/jbc.RA120.016103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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