7K2R

Kelch domain of human KEAP1 bound to Nrf2-based cyclic peptide, c[LhA-DEETGE]

Summary for 7K2R

Entry DOI	10.2210/pdb7k2r/pdb
Descriptor	Kelch-like ECH-associated protein 1, B3A-ASP-PRO-GLU-THR-GLY-GLU, SULFATE ION, ... (4 entities in total)
Functional Keywords	peptide inhibitor, inhibitor complex, loop-mimic, protein binding, cyclic peptide
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	64314.78
Authors	Muellers, S.N.,Allen, K.N. (deposition date: 2020-09-08, release date: 2021-04-07, Last modification date: 2023-11-15)
Primary citation	Ortet, P.C.,Muellers, S.N.,Viarengo-Baker, L.A.,Streu, K.,Szymczyna, B.R.,Beeler, A.B.,Allen, K.N.,Whitty, A. Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning. J.Am.Chem.Soc., 143:3779-3793, 2021 Cited by PubMed: 33683866 DOI: 10.1021/jacs.0c09799 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation