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7K27

Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR inhibitor AZ20

Summary for 7K27
Entry DOI10.2210/pdb7k27/pdb
DescriptorTranscription initiation factor TFIID subunit 1, 1,2-ETHANEDIOL, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole, ... (6 entities in total)
Functional Keywordsbromodomain, taf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, transferase, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight31799.26
Authors
Karim, M.R.,Schonbrunn, E. (deposition date: 2020-09-08, release date: 2021-09-22, Last modification date: 2023-10-18)
Primary citationKarim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E.
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
J.Med.Chem., 65:4182-4200, 2022
Cited by
PubMed: 35191694
DOI: 10.1021/acs.jmedchem.1c01999
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

221051

數據於2024-06-12公開中

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