Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7K1P

Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine

Summary for 7K1P
Entry DOI10.2210/pdb7k1p/pdb
DescriptorTranscription initiation factor TFIID subunit 1, Bromosporine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstaf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight16349.32
Authors
Karim, M.R.,Schonbrunn, E. (deposition date: 2020-09-08, release date: 2021-09-22, Last modification date: 2023-10-18)
Primary citationKarim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E.
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
J.Med.Chem., 65:4182-4200, 2022
Cited by
PubMed: 35191694
DOI: 10.1021/acs.jmedchem.1c01999
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

221051

数据于2024-06-12公开中

PDB statisticsPDBj update infoContact PDBjnumon