7K1I

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

7K1I の概要

• エントリーDOI: 10.2210/pdb7k1i/pdb
• 分子名称: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38825.69

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2020-09-07, 公開日: 2021-09-15, 最終更新日: 2023-10-18)

• 主引用文献: Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J.; Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors; Nat Commun, 13:2530-, 2022; DOI: 10.1038/s41467-022-30258-y

実験手法

X-RAY DIFFRACTION (3.202 Å)