7K0Q

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, myriocin-bound

Summary for 7K0Q

• Entry DOI: 10.2210/pdb7k0q/pdb
• EMDB information: 22608
• Descriptor: Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, Serine palmitoyltransferase small subunit A, ... (6 entities in total)
• Functional Keywords: sphingolipid, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 142443.30

Authors

Wang, Y.,Niu, Y.,Zhang, Z.,Zhao, H.,Myasnikov, A.,Kalathur, R.,Lee, C.H. (deposition date: 2020-09-04, release date: 2021-02-24, Last modification date: 2024-03-06)

• Primary citation: Wang, Y.,Niu, Y.,Zhang, Z.,Gable, K.,Gupta, S.D.,Somashekarappa, N.,Han, G.,Zhao, H.,Myasnikov, A.G.,Kalathur, R.C.,Dunn, T.M.,Lee, C.H.; Structural insights into the regulation of human serine palmitoyltransferase complexes.; Nat.Struct.Mol.Biol., 28:240-248, 2021; PubMed: 33558761; DOI: 10.1038/s41594-020-00551-9

Experimental method

ELECTRON MICROSCOPY (3.3 Å)