7K03
Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738
Summary for 7K03
Entry DOI | 10.2210/pdb7k03/pdb |
Descriptor | Transcription initiation factor TFIID subunit 1, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | taf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, transferase, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31631.05 |
Authors | Karim, M.R.,Schonbrunn, E. (deposition date: 2020-09-03, release date: 2021-09-22, Last modification date: 2023-10-18) |
Primary citation | Karim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E. Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65:4182-4200, 2022 Cited by PubMed: 35191694DOI: 10.1021/acs.jmedchem.1c01999 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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