7JYD
Human Liver Receptor Homolog-1 in Complex with 10CA and a Fragment of Tif2
Summary for 7JYD
Entry DOI | 10.2210/pdb7jyd/pdb |
Descriptor | Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, 10-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid, ... (4 entities in total) |
Functional Keywords | agonist, nuclear receptor, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 30353.19 |
Authors | D'Agostino, E.H.,Mays, S.G.,Ortlund, E.A. (deposition date: 2020-08-30, release date: 2022-03-02, Last modification date: 2023-10-18) |
Primary citation | D'Agostino, E.H.,Mays, S.G.,Flynn, A.F.,Huang, X.,Wang, G.,Liu, X.,Millings, E.J.,Okafor, C.D.,Patel, A.,Cato, M.L.,Cornelison, J.C.,Houtman, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A. Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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