7JXT

Ovine COX-1 in complex with the subtype-selective derivative 2a

7JXT の概要

• エントリーDOI: 10.2210/pdb7jxt/pdb
• 分子名称: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: cyclooxygenase-1, oxidoreductase inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Ovis aries (Sheep)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 132390.55

構造登録者

Ko, Y.,Iaselli, M.,Miciaccia, M.,Friedrich, L.,Schneider, G.,Scilimati, A.,Cingolani, G. (登録日: 2020-08-27, 公開日: 2021-09-01, 最終更新日: 2023-10-18)

• 主引用文献: Friedrich, L.,Cingolani, G.,Ko, Y.H.,Iaselli, M.,Miciaccia, M.,Perrone, M.G.,Neukirch, K.,Bobinger, V.,Merk, D.,Hofstetter, R.K.,Werz, O.,Koeberle, A.,Scilimati, A.,Schneider, G.; Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design.; Adv Sci, 8:e2100832-e2100832, 2021; PubMed: 34176236; DOI: 10.1002/advs.202100832

実験手法

X-RAY DIFFRACTION (3.35 Å)