7JXQ

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Summary for 7JXQ

Entry DOI	10.2210/pdb7jxq/pdb
Descriptor	Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	155247.00
Authors	Beyett, T.S.,Eck, M.J. (deposition date: 2020-08-27, release date: 2021-09-08, Last modification date: 2023-10-18)
Primary citation	To, C.,Beyett, T.S.,Jang, J.,Feng, W.W.,Bahcall, M.,Haikala, H.M.,Shin, B.H.,Heppner, D.E.,Rana, J.K.,Leeper, B.A.,Soroko, K.M.,Poitras, M.J.,Gokhale, P.C.,Kobayashi, Y.,Wahid, K.,Kurppa, K.J.,Gero, T.W.,Cameron, M.D.,Ogino, A.,Mushajiang, M.,Xu, C.,Zhang, Y.,Scott, D.A.,Eck, M.J.,Gray, N.S.,Janne, P.A. An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nat Cancer, 3:402-417, 2022 Cited by PubMed: 35422503 DOI: 10.1038/s43018-022-00351-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation