7JXQ

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

7JXQ の概要

• エントリーDOI: 10.2210/pdb7jxq/pdb
• 分子名称: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 155247.00

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2020-08-27, 公開日: 2021-09-08, 最終更新日: 2023-10-18)

• 主引用文献: To, C.,Beyett, T.S.,Jang, J.,Feng, W.W.,Bahcall, M.,Haikala, H.M.,Shin, B.H.,Heppner, D.E.,Rana, J.K.,Leeper, B.A.,Soroko, K.M.,Poitras, M.J.,Gokhale, P.C.,Kobayashi, Y.,Wahid, K.,Kurppa, K.J.,Gero, T.W.,Cameron, M.D.,Ogino, A.,Mushajiang, M.,Xu, C.,Zhang, Y.,Scott, D.A.,Eck, M.J.,Gray, N.S.,Janne, P.A.; An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.; Nat Cancer, 3:402-417, 2022; PubMed: 35422503; DOI: 10.1038/s43018-022-00351-8

実験手法