7JXH

HER2 in complex with JBJ-08-178-01

Summary for 7JXH

• Entry DOI: 10.2210/pdb7jxh/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, (2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide (2 entities in total)
• Functional Keywords: her2, erbb2, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 299577.07

Authors

Beyett, T.S.,Eck, M.J. (deposition date: 2020-08-27, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Son, J.,Jang, J.,Beyett, T.S.,Eum, Y.,Haikala, H.M.,Verano, A.,Lin, M.,Hatcher, J.M.,Kwiatkowski, N.P.,Eser, P.O.,Poitras, M.J.,Wang, S.,Xu, M.,Gokhale, P.C.,Cameron, M.D.,Eck, M.J.,Gray, N.S.,Janne, P.A.; A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.; Cancer Res., 82:1633-1645, 2022; PubMed: 35149586; DOI: 10.1158/0008-5472.CAN-21-2693

Experimental method

X-RAY DIFFRACTION (3.27 Å)