7JXH

HER2 in complex with JBJ-08-178-01

7JXH の概要

• エントリーDOI: 10.2210/pdb7jxh/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2, (2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide (2 entities in total)
• 機能のキーワード: her2, erbb2, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 299577.07

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2020-08-27, 公開日: 2021-09-08, 最終更新日: 2023-10-18)

• 主引用文献: Son, J.,Jang, J.,Beyett, T.S.,Eum, Y.,Haikala, H.M.,Verano, A.,Lin, M.,Hatcher, J.M.,Kwiatkowski, N.P.,Eser, P.O.,Poitras, M.J.,Wang, S.,Xu, M.,Gokhale, P.C.,Cameron, M.D.,Eck, M.J.,Gray, N.S.,Janne, P.A.; A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.; Cancer Res., 82:1633-1645, 2022; PubMed: 35149586; DOI: 10.1158/0008-5472.CAN-21-2693

実験手法

X-RAY DIFFRACTION (3.27 Å)