7JX9
The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1S,3S)-3-amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid.
7JX9 の概要
エントリーDOI | 10.2210/pdb7jx9/pdb |
分子名称 | Ornithine aminotransferase, mitochondrial, (1S,3S,4S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-(1,1,3,3,3-pentafluoroprop-1-en-2-yl)cyclopentane-1-carboxylic acid, N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine, ... (4 entities in total) |
機能のキーワード | ornithine, aminotransferase, plp, mechanism-based inactivator, intermediate, irreversible inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 136404.20 |
構造登録者 | Butrin, A.,Beaupre, B.,Shen, S.,Silverman, R.B.,Moran, G.,Liu, D. (登録日: 2020-08-26, 公開日: 2021-01-06, 最終更新日: 2023-10-18) |
主引用文献 | Butrin, A.,Beaupre, B.A.,Kadamandla, N.,Zhao, P.,Shen, S.,Silverman, R.B.,Moran, G.R.,Liu, D. Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF 3 ). Acs Chem.Biol., 16:67-75, 2021 Cited by PubMed: 33316155DOI: 10.1021/acschembio.0c00728 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.96 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)