7JWU
Crystal structure of human ALDH1A1 bound to compound (R)-28
Summary for 7JWU
Entry DOI | 10.2210/pdb7jwu/pdb |
Descriptor | Retinal dehydrogenase 1, YTTERBIUM (III) ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | rossmann fold, cytosolic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 56341.44 |
Authors | Hurley, T.D.,Buchman, C. (deposition date: 2020-08-26, release date: 2020-12-30, Last modification date: 2023-10-18) |
Primary citation | Huddle, B.C.,Grimley, E.,Chtcherbinine, M.,Buchman, C.D.,Takahashi, C.,Debnath, B.,McGonigal, S.C.,Mao, S.,Li, S.,Felton, J.,Pan, S.,Wen, B.,Sun, D.,Neamati, N.,Buckanovich, R.J.,Hurley, T.D.,Larsen, S.D. Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. Eur.J.Med.Chem., 211:113060-113060, 2020 Cited by PubMed: 33341649DOI: 10.1016/j.ejmech.2020.113060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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