7JWU

Crystal structure of human ALDH1A1 bound to compound (R)-28

7JWU の概要

• エントリーDOI: 10.2210/pdb7jwu/pdb
• 分子名称: Retinal dehydrogenase 1, YTTERBIUM (III) ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: rossmann fold, cytosolic protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56341.44

構造登録者

Hurley, T.D.,Buchman, C. (登録日: 2020-08-26, 公開日: 2020-12-30, 最終更新日: 2023-10-18)

• 主引用文献: Huddle, B.C.,Grimley, E.,Chtcherbinine, M.,Buchman, C.D.,Takahashi, C.,Debnath, B.,McGonigal, S.C.,Mao, S.,Li, S.,Felton, J.,Pan, S.,Wen, B.,Sun, D.,Neamati, N.,Buckanovich, R.J.,Hurley, T.D.,Larsen, S.D.; Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.; Eur.J.Med.Chem., 211:113060-113060, 2020; PubMed: 33341649; DOI: 10.1016/j.ejmech.2020.113060

実験手法

X-RAY DIFFRACTION (1.9 Å)