7JVW

Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344

7JVW の概要

• エントリーDOI: 10.2210/pdb7jvw/pdb
• 分子名称: Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase, cornelia de lange syndrome (cdls)
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87566.26

構造登録者

Osko, J.D.,Christianson, D.W.,Decroos, C.,Porter, N.J.,Lee, M. (登録日: 2020-08-24, 公開日: 2020-12-16, 最終更新日: 2023-10-18)

• 主引用文献: Osko, J.D.,Porter, N.J.,Decroos, C.,Lee, M.S.,Watson, P.R.,Raible, S.E.,Krantz, I.D.,Deardorff, M.A.,Christianson, D.W.; Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.; J.Struct.Biol., 213:107681-107681, 2020; PubMed: 33316326; DOI: 10.1016/j.jsb.2020.107681

実験手法

X-RAY DIFFRACTION (2.40301779656 Å)