7JVV

Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate

Summary for 7JVV

Entry DOI	10.2210/pdb7jvv/pdb
Descriptor	Histone deacetylase 8, ACE-ARG-HIS-ALY-ALY-MCM, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	histone deacetylase, hydrolase, cornelia de lange syndrome (cdls)
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	89045.83
Authors	Osko, J.D.,Christianson, D.W.,Decroos, C.,Porter, N.J.,Lee, M. (deposition date: 2020-08-24, release date: 2020-12-16, Last modification date: 2023-11-15)
Primary citation	Osko, J.D.,Porter, N.J.,Decroos, C.,Lee, M.S.,Watson, P.R.,Raible, S.E.,Krantz, I.D.,Deardorff, M.A.,Christianson, D.W. Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213:107681-107681, 2020 Cited by PubMed: 33316326 DOI: 10.1016/j.jsb.2020.107681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation