7JVO

Importin alpha bound to the C-terminus of ACE2

Summary for 7JVO

Entry DOI	10.2210/pdb7jvo/pdb
Descriptor	Importin subunit alpha-1, ARG-LYS-LYS-LYS-ASN-LYS-ALA (3 entities in total)
Functional Keywords	importin, karyopherin, ace2, transport protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	56962.40
Authors	Forwood, J.K.,Cross, E.M.,Tsimbalyuk, S. (deposition date: 2020-08-22, release date: 2020-10-14, Last modification date: 2023-10-18)
Primary citation	Tu, W.J.,McCuaig, R.D.,Melino, M.,Rawle, D.J.,Le, T.T.,Yan, K.,Suhrbier, A.,Johnston, R.L.,Koufariotis, L.T.,Waddell, N.,Cross, E.M.,Tsimbalyuk, S.,Bain, A.,Ahern, E.,Collinson, N.,Phipps, S.,Forwood, J.K.,Seddiki, N.,Rao, S. Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication. Cell Discov, 7:37-37, 2021 Cited by PubMed: 34031383 DOI: 10.1038/s41421-021-00279-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation