7JV8

Human CD73 (ecto 5'-nucleotidase) in complex with compound 35

7JV8 の概要

• エントリーDOI: 10.2210/pdb7jv8/pdb
• 分子名称: 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: 5'-nucleotidase, hydrolase, phosphatase, proteros, proteros biostructures gmbh, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 237898.68

構造登録者

Gibbons, P.,Du, X. (登録日: 2020-08-20, 公開日: 2020-09-23, 最終更新日: 2023-10-18)

• 主引用文献: Du, X.,Moore, J.,Blank, B.R.,Eksterowicz, J.,Sutimantanapi, D.,Yuen, N.,Metzger, T.,Chan, B.,Huang, T.,Chen, X.,Chen, Y.,Duong, F.,Kong, W.,Chang, J.H.,Sun, J.,Zavorotinskaya, T.,Ye, Q.,Junttila, M.R.,Ndubaku, C.,Friedman, L.S.,Fantin, V.R.,Sun, D.; Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.; J.Med.Chem., 63:10433-10459, 2020; PubMed: 32865411; DOI: 10.1021/acs.jmedchem.0c01086

実験手法

X-RAY DIFFRACTION (2.46 Å)