7JUP
Structure of human TRPA1 in complex with antagonist compound 21
Summary for 7JUP
Entry DOI | 10.2210/pdb7jup/pdb |
EMDB information | 22490 |
Descriptor | Transient receptor potential cation channel subfamily A member 1, 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one (2 entities in total) |
Functional Keywords | trpa1, channel, agonist, membrane protein, membrane protein-antagonist complex, membrane protein/antagonist |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 292074.00 |
Authors | |
Primary citation | Terrett, J.A.,Chen, H.,Shore, D.G.,Villemure, E.,Larouche-Gauthier, R.,Dery, M.,Beaumier, F.,Constantineau-Forget, L.,Grand-Maitre, C.,Lepissier, L.,Ciblat, S.,Sturino, C.,Chen, Y.,Hu, B.,Lu, A.,Wang, Y.,Cridland, A.P.,Ward, S.I.,Hackos, D.H.,Reese, R.M.,Shields, S.D.,Chen, J.,Balestrini, A.,Riol-Blanco, L.,Lee, W.P.,Liu, J.,Suto, E.,Wu, X.,Zhang, J.,Ly, J.Q.,La, H.,Johnson, K.,Baumgardner, M.,Chou, K.J.,Rohou, A.,Rouge, L.,Safina, B.S.,Magnuson, S.,Volgraf, M. Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J.Med.Chem., 64:3843-3869, 2021 Cited by PubMed: 33749283DOI: 10.1021/acs.jmedchem.0c02023 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.05 Å) |
Structure validation
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