7JUM

Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01

7JUM の概要

• エントリーDOI: 10.2210/pdb7jum/pdb
• 分子名称: Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv (3 entities in total)
• 機能のキーワード: pfs230d1, pfs230, monoclonal antibody, cell invasion
• 由来する生物種: Plasmodium falciparum (isolate 3D7); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 147108.20

構造登録者

Tolia, N.,Tang, W.K. (登録日: 2020-08-20, 公開日: 2021-03-31, 最終更新日: 2021-04-07)

• 主引用文献: Coelho, C.H.,Tang, W.K.,Burkhardt, M.,Galson, J.D.,Muratova, O.,Salinas, N.D.,Alves E Silva, T.L.,Reiter, K.,MacDonald, N.J.,Nguyen, V.,Herrera, R.,Shimp, R.,Narum, D.L.,Byrne-Steele, M.,Pan, W.,Hou, X.,Brown, B.,Eisenhower, M.,Han, J.,Jenkins, B.J.,Doritchamou, J.Y.A.,Smelkinson, M.G.,Vega-Rodriguez, J.,Truck, J.,Taylor, J.J.,Sagara, I.,Renn, J.P.,Tolia, N.H.,Duffy, P.E.; A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.; Nat Commun, 12:1750-1750, 2021; PubMed: 33741942; DOI: 10.1038/s41467-021-21955-1

実験手法

X-RAY DIFFRACTION (1.998 Å)