7JUJ

Cruzain bound to Gallinamide inhibitor

Summary for 7JUJ

Entry DOI	10.2210/pdb7juj/pdb
Descriptor	Cruzipain, gallinamide A, bound form, POTASSIUM ION, ... (4 entities in total)
Functional Keywords	cysteine protease, cruzain, gallinamide, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Trypanosoma cruzi
Total number of polymer chains	6
Total formula weight	140406.87
Authors	Silva, E.B.,Sharma, V.,Alvarez, L.H.,Gerwick, W.H.,McKerrow, J.H.,Podust, L.M. (deposition date: 2020-08-19, release date: 2021-08-25, Last modification date: 2023-10-18)
Primary citation	Barbosa Da Silva, E.,Sharma, V.,Hernandez-Alvarez, L.,Tang, A.H.,Stoye, A.,O'Donoghue, A.J.,Gerwick, W.H.,Payne, R.J.,McKerrow, J.H.,Podust, L.M. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi . J.Med.Chem., 65:4255-4269, 2022 Cited by PubMed: 35188371 DOI: 10.1021/acs.jmedchem.1c02063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation