7JTQ
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases
Summary for 7JTQ
Entry DOI | 10.2210/pdb7jtq/pdb |
Descriptor | Complement factor B, DNA (32-MER) (2 entities in total) |
Functional Keywords | complement, protease, convertase, inhibitor, aptamer, immune system, immune system-dna complex, immune system/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 194163.50 |
Authors | Xu, X.,Geisbrecht, B.V. (deposition date: 2020-08-18, release date: 2020-12-09, Last modification date: 2023-10-18) |
Primary citation | Xu, X.,Zhang, C.,Denton, D.T.,O'Connell, D.,Drolet, D.W.,Geisbrecht, B.V. Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol., 206:861-873, 2021 Cited by PubMed: 33419768DOI: 10.4049/jimmunol.2001260 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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