7JTN

Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases

7JTN の概要

• エントリーDOI: 10.2210/pdb7jtn/pdb
• 分子名称: Complement factor B, DNA (30-MER) (2 entities in total)
• 機能のキーワード: complement, protease, convertase, inhibitor, aptamer, immune system, immune system-dna complex, immune system/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192806.62

構造登録者

Xu, X.,Geisbrecht, B.V. (登録日: 2020-08-18, 公開日: 2020-12-09, 最終更新日: 2023-10-18)

• 主引用文献: Xu, X.,Zhang, C.,Denton, D.T.,O'Connell, D.,Drolet, D.W.,Geisbrecht, B.V.; Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.; J Immunol., 206:861-873, 2021; PubMed: 33419768; DOI: 10.4049/jimmunol.2001260

実験手法

X-RAY DIFFRACTION (3.1 Å)