7JSP

Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738

7JSP の概要

• エントリーDOI: 10.2210/pdb7jsp/pdb
• 分子名称: Transcription initiation factor TFIID subunit 1, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bromodomain, taf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16455.47

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2020-08-15, 公開日: 2021-08-25, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E.; Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.; J.Med.Chem., 65:4182-4200, 2022; PubMed: 35191694; DOI: 10.1021/acs.jmedchem.1c01999

実験手法

X-RAY DIFFRACTION (1.7 Å)