7JQS

Abeta 16-36 beta-hairpin mimic with E22delta Osaka mutation

7JQS の概要

• エントリーDOI: 10.2210/pdb7jqs/pdb
• 分子名称: Abeta 16-36 beta-hairpin mimic VAL-ORN-LYS-LEU-VAL-MEA-PHE-ALA-ASP-ORN-ALA-ILE-ILE-GLY-LEU-MET (2 entities in total)
• 機能のキーワード: alzheimer's disease, amyloid, abeta, oligomer, familial mutant, de novo protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1780.24

構造登録者

Kreutzer, A.G.,McKnelly, K.J.,Nowick, J.S. (登録日: 2020-08-11, 公開日: 2021-09-08, 最終更新日: 2023-10-18)

• 主引用文献: McKnelly, K.J.,Kreutzer, A.G.,Howitz, W.J.,Haduong, K.,Yoo, S.,Hart, C.,Nowick, J.S.; Effects of Familial Alzheimer's Disease Mutations on the Assembly of a beta-Hairpin Peptide Derived from A beta 16-36 .; Biochemistry, 61:446-454, 2022; PubMed: 35213141; DOI: 10.1021/acs.biochem.1c00664

実験手法

X-RAY DIFFRACTION (2.127 Å)