7JQD
Crystal Structure of PAC1r in complex with peptide antagonist
Summary for 7JQD
Entry DOI | 10.2210/pdb7jqd/pdb |
Descriptor | Pituitary adenylate cyclase-activating polypeptide type I receptor, Peptide-43 (3 entities in total) |
Functional Keywords | ecd, complex, antagonist, gpcr, signaling protein-antagonist complex, signaling protein/antagonist |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 16248.37 |
Authors | Piper, D.E.,Hu, E.,Fang-Tsao, H. (deposition date: 2020-08-10, release date: 2021-03-24, Last modification date: 2023-10-18) |
Primary citation | Hu, E.,Hong, F.T.,Aral, J.,Long, J.,Piper, D.E.,Poppe, L.,Andrews, K.L.,Hager, T.,Davis, C.,Li, H.,Wong, P.,Gavva, N.,Shi, L.,Zhu, D.X.D.,Lehto, S.G.,Xu, C.,Miranda, L.P. Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model. J.Med.Chem., 64:3427-3438, 2021 Cited by PubMed: 33715378DOI: 10.1021/acs.jmedchem.0c01396 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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