7JNT
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A POTENT AND SELECTIVE DUAL ROCK INHIBITOR
7JNT の概要
エントリーDOI | 10.2210/pdb7jnt/pdb |
分子名称 | Rho-associated protein kinase 2, N-[(3-methoxyphenyl)methyl]-5H-[1]benzopyrano[3,4-c]pyridine-8-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
機能のキーワード | rock 2, kinase, transferase, transferase-transferase inhibit complex, transferase-transferase inhibitor complex |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 369656.13 |
構造登録者 | |
主引用文献 | Hu, Z.,Wang, C.,Sitkoff, D.,Cheadle, N.L.,Xu, S.,Muckelbauer, J.K.,Adam, L.P.,Wexler, R.R.,Quan, M.L. Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors. Bioorg.Med.Chem.Lett., 30:127474-127474, 2020 Cited by PubMed: 32805407DOI: 10.1016/j.bmcl.2020.127474 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.214 Å) |
構造検証レポート
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