7JM5

Crystal structure of KDM4B in complex with QC6352

7JM5 の概要

• エントリーDOI: 10.2210/pdb7jm5/pdb
• 分子名称: Lysine-specific demethylase 4B, NICKEL (II) ION, 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: kdm4, kdm4b, protein-inhibitor complex, demethylase, epigenetics, oxidoreductase-inhibitor complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85377.59

構造登録者

White, S.W.,Yun, M. (登録日: 2020-07-31, 公開日: 2022-02-02, 最終更新日: 2023-10-18)

• 主引用文献: Singh, S.,Abu-Zaid, A.,Jin, H.,Fang, J.,Wu, Q.,Wang, T.,Feng, H.,Quarni, W.,Shao, Y.,Maxham, L.,Abdolvahabi, A.,Yun, M.K.,Vaithiyalingam, S.,Tan, H.,Bowling, J.,Honnell, V.,Young, B.,Guo, Y.,Bajpai, R.,Pruett-Miller, S.M.,Grosveld, G.C.,Hatley, M.,Xu, B.,Fan, Y.,Wu, G.,Chen, E.Y.,Chen, T.,Lewis, P.W.,Rankovic, Z.,Li, Y.,Murphy, A.J.,Easton, J.,Peng, J.,Chen, X.,Wang, R.,White, S.W.,Davidoff, A.M.,Yang, J.; Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.; Sci Transl Med, 14:eabq2096-eabq2096, 2022; PubMed: 35857643; DOI: 10.1126/scitranslmed.abq2096

実験手法

X-RAY DIFFRACTION (2.7 Å)