7JJG

Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZ20

7JJG の概要

• エントリーDOI: 10.2210/pdb7jjg/pdb
• 分子名称: Transcription initiation factor TFIID subunit 1, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bromodomain, taf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, transferase-transferase inhibitor complex, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16449.48

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2020-07-25, 公開日: 2021-07-28, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E.; Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.; J.Med.Chem., 65:4182-4200, 2022; PubMed: 35191694; DOI: 10.1021/acs.jmedchem.1c01999

実験手法

X-RAY DIFFRACTION (1.6 Å)