7JGV

CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2

7JGV の概要

• エントリーDOI: 10.2210/pdb7jgv/pdb
• 分子名称: Bcl-2-like protein 1, 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid (3 entities in total)
• 機能のキーワード: poptosis, alternative splicing, membrane, mitochondrion, apoptosis
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37071.35

構造登録者

Lee, M.,Fairlie, W.D.,Smith, B.J.,Lee, E.F. (登録日: 2020-07-19, 公開日: 2021-02-24, 最終更新日: 2023-10-18)

• 主引用文献: Nguyen, W.,Lee, E.F.,Evangelista, M.,Lee, M.,Harris, T.J.,Colman, P.M.,Smith, N.A.,Williams, L.B.,Jarman, K.E.,Lowes, K.N.,Haeberli, C.,Keiser, J.,Smith, B.J.,Fairlie, W.D.,Sleebs, B.E.; Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.; Acs Infect Dis., 7:1143-1163, 2021; PubMed: 33523649; DOI: 10.1021/acsinfecdis.0c00700

実験手法

X-RAY DIFFRACTION (2.05 Å)