7H4Q

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z59181971 (A71EV2A-x1080)

Summary for 7H4Q

Entry DOI	10.2210/pdb7h4q/pdb
Group deposition	Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease (G_1002288)
Descriptor	Protease 2A, N-hydroxypropanamide, ZINC ION, ... (5 entities in total)
Functional Keywords	diamond light source, i03, asap, coxsackievirus a16, crystallographic fragment screening, pandda, pandda2, xchemexplorer, viral protein, hydrolase
Biological source	Coxsackievirus A16 More
Total number of polymer chains	1
Total formula weight	16725.95
Authors	Lithgo, R.M.,Fairhead, M.,Koekemoer, L.,Balcomb, B.H.,Capkin, E.,Chandran, A.V.,Golding, M.,Godoy, A.S.,Aschenbrenner, J.C.,Marples, P.G.,Ni, X.,Thompson, W.,Tomlinson, C.W.E.,Wild, C.,Winokan, M.,Xavier, M.-A.E.,Fearon, D.,von Delft, F. (deposition date: 2024-04-04, release date: 2024-04-24, Last modification date: 2024-10-16)
Primary citation	Lithgo, R.M.,Tomlinson, C.W.E.,Fairhead, M.,Winokan, M.,Thompson, W.,Wild, C.,Aschenbrenner, J.C.,Balcomb, B.H.,Marples, P.G.,Chandran, A.V.,Golding, M.,Koekemoer, L.,Williams, E.P.,Wang, S.,Ni, X.,MacLean, E.,Giroud, C.,Godoy, A.S.,Xavier, M.A.,Walsh, M.,Fearon, D.,von Delft, F. Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024 Cited by PubMed: 38746446 DOI: 10.1101/2024.04.29.591684 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation