7GT3

PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000527a

これはPDB形式変換不可エントリーです。

7GT3 の概要

• エントリーDOI: 10.2210/pdb7gt3/pdb
• Group deposition: PanDDA Analysis group deposition (G_1002284)
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ethyl (3R,3aS,8bS)-1-acetyl-5-methyl-2,3,3a,8b-tetrahydro-1H-[1]benzofuro[3,2-b]pyrrole-3-carboxylate, ... (4 entities in total)
• 機能のキーワード: pandda, diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37757.03

構造登録者

Mehlman, T.,Ginn, H.M.,Keedy, D.A. (登録日: 2024-01-03, 公開日: 2024-01-24, 最終更新日: 2024-04-24)

• 主引用文献: Mehlman, T.S.,Ginn, H.M.,Keedy, D.A.; An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data.; Biorxiv, 2024; PubMed: 38260327; DOI: 10.1101/2024.01.05.574428

実験手法

X-RAY DIFFRACTION (1.59 Å)