7GQE
PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3C Protease in complex with Z57473948
Summary for 7GQE
Entry DOI | 10.2210/pdb7gqe/pdb |
Group deposition | PanDDA analysis group deposition (G_1002271) |
Descriptor | Protease 3C, N-cyclopropyl-2-hydroxybenzamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | diamond i04-1 fragment screening, pandda, xchemexplorer, xce, viral protease, 3c, viral protein |
Biological source | Human Enterovirus D68 |
Total number of polymer chains | 2 |
Total formula weight | 40507.35 |
Authors | Lithgo, R.M.,Fairhead, M.,Koekemoer, L.,Aschenbrenner, J.C.,Balcomb, B.H.,Godoy, A.S.,Marples, P.G.,Ni, X.,Tomlinson, C.W.E.,Thompson, W.,Wild, C.,Fearon, D.,Walsh, M.A.,von Delft, F. (deposition date: 2023-08-24, release date: 2023-11-29, Last modification date: 2024-10-16) |
Primary citation | Lithgo, R.M.,Tomlinson, C.W.E.,Fairhead, M.,Winokan, M.,Thompson, W.,Wild, C.,Aschenbrenner, J.C.,Balcomb, B.H.,Marples, P.G.,Chandran, A.V.,Golding, M.,Koekemoer, L.,Williams, E.P.,Wang, S.,Ni, X.,MacLean, E.,Giroud, C.,Godoy, A.S.,Xavier, M.A.,Walsh, M.,Fearon, D.,von Delft, F. Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024 Cited by PubMed: 38746446DOI: 10.1101/2024.04.29.591684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.44 Å) |
Structure validation
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