7FTL

Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid

Summary for 7FTL

• Entry DOI: 10.2210/pdb7ftl/pdb
• Group deposition: To be published (G_1002263)
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, (2P)-8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42770.02

Authors

Leibrock, L.,Benz, J.,Groebke-Zbinden, K.,Brunner, M.,Rudolph, M.G. (deposition date: 2023-02-08, release date: 2024-02-21)

• Primary citation: Groebke-Zbinden, K.,Vandemeulebroucke, A.,Hilbert, M.,Rudolph, M.G.; Crystal Structure of a human cyclic GMP-AMP synthase complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)