7FQP
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000505a
Summary for 7FQP
Entry DOI | 10.2210/pdb7fqp/pdb |
Group deposition | PanDDA analysis group deposition (G_1002251) |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, (6R)-5,6-dihydro-1H-2,6-methano-1lambda~6~-1lambda~6~,2,5-benzothiadiazocine-1,1,4(3H)-trione, ... (4 entities in total) |
Functional Keywords | pandda, diamond i24 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37705.97 |
Authors | Mehlman, T.,Biel, J.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.E.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. (deposition date: 2022-10-19, release date: 2022-11-23, Last modification date: 2024-05-22) |
Primary citation | Skaist Mehlman, T.,Biel, J.T.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. Elife, 12:-, 2023 Cited by PubMed: 36881464DOI: 10.7554/eLife.84632 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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