7FQI
Crystal Structure of human Legumain in complex with (2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[1-[4-[(2,4-difluorophenyl)methoxy]phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide
Summary for 7FQI
Entry DOI | 10.2210/pdb7fqi/pdb |
Group deposition | To be published (G_1002245) |
Descriptor | Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2R)-4-amino-1-imino-4-oxobutan-2-yl]-1-(1-{4-[(2,4-difluorophenyl)methoxy]phenyl}cyclopropane-1-carbonyl)-L-prolinamide, ... (5 entities in total) |
Functional Keywords | cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 155712.13 |
Authors | Ehler, A.,Benz, J.,Bartels, B.,Rudolph, M.G. (deposition date: 2022-10-05, release date: 2023-10-11, Last modification date: 2023-11-15) |
Primary citation | Bartels, B.,Kuhn, B.,Benz, J.,Rudolph, M.G. Crystal Structure of a human Legumain complex To be published, |
Experimental method |
Structure validation
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