7FJ3

Cryo-EM structure of PRV A-capid

これはPDB形式変換不可エントリーです。

7FJ3 の概要

• エントリーDOI: 10.2210/pdb7fj3/pdb
• EMDBエントリー: 31612
• 分子名称: Major capsid protein, Triplex capsid protein 2, Triplex capsid protein 1, ... (4 entities in total)
• 機能のキーワード: pseudorabies virus, c-capsid, cryo-em, virus
• 由来する生物種: Suid alphaherpesvirus 1; 詳細
• タンパク質・核酸の鎖数: 51
• 化学式量合計: 3227993.48

構造登録者

Zheng, Q.,Li, S.,Zha, Z.,Sun, H. (登録日: 2021-08-02, 公開日: 2022-06-22, 最終更新日: 2024-10-23)

主引用文献

Wang, G.,Zha, Z.,Huang, P.,Sun, H.,Huang, Y.,He, M.,Chen, T.,Lin, L.,Chen, Z.,Kong, Z.,Que, Y.,Li, T.,Gu, Y.,Yu, H.,Zhang, J.,Zheng, Q.,Chen, Y.,Li, S.,Xia, N.
Structures of pseudorabies virus capsids.
Nat Commun, 13:1533-1533, 2022

PubMed Abstract: Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that PRV may be able to overcome the species barrier to infect humans. To date, there is no available therapeutic for PRV infection. Here, we report the near-atomic structures of the PRV A-capsid and C-capsid, and illustrate the interaction that occurs between these subunits. We show that the C-capsid portal complex is decorated with capsid-associated tegument complexes. The PRV capsid structure is highly reminiscent of other α-herpesviruses, with some additional structural features of β- and γ-herpesviruses. These results illustrate the structure of the PRV capsid and elucidate the underlying assembly mechanism at the molecular level. This knowledge may be useful for the development of oncolytic agents or specific therapeutics against this arm of the herpesvirus family.

PubMed: 35318331
DOI: 10.1038/s41467-022-29250-3

実験手法

ELECTRON MICROSCOPY (4.53 Å)