7FIO

LecA from Pseudomonas aeruginosa in complex with a synthetic monovalent galactosidic inhibitor

Summary for 7FIO

• Entry DOI: 10.2210/pdb7fio/pdb
• Descriptor: PA-I galactophilic lectin, CALCIUM ION, N-[2-[4-[(2S)-3-(2-hydroxyethylamino)-3-oxidanylidene-2-(2-phenoxyethanoylamino)propyl]-1,2,3-triazol-1-yl]ethyl]-4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanyl-benzamide, ... (5 entities in total)
• Functional Keywords: lectin, carbohydrates, glycoconjugate, glycomimetics, leca, sugar binding protein
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 4
• Total formula weight: 54125.95

Authors

Kuhaudomlarp, S.,Siebs, E.,da Silva Figueiredo Celestino Gomes, P.,Fortin, C.,Rognan, D.,Rademacher, C.,Imberty, A.,Titz, A. (deposition date: 2021-07-31, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Siebs, E.,Shanina, E.,Kuhaudomlarp, S.,da Silva Figueiredo Celestino Gomes, P.,Fortin, C.,Seeberger, P.H.,Rognan, D.,Rademacher, C.,Imberty, A.,Titz, A.; Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA.; Chembiochem, 23:e202100563-e202100563, 2022; PubMed: 34788491; DOI: 10.1002/cbic.202100563

Experimental method

X-RAY DIFFRACTION (1.5 Å)