7FIC
Reversible lysine-targeted probes reveal residence time-based kinase selectivity in vivo
Summary for 7FIC
Entry DOI | 10.2210/pdb7fic/pdb |
Descriptor | Aurora kinase A, 6-[(5-cyclopropyl-1~{H}-pyrazol-3-yl)amino]-2-[4-[(3-methyl-4-oxidanyl-phenyl)methyl]piperazin-1-yl]-~{N}-prop-2-ynyl-pyrimidine-4-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | reversible lysine-targeted inhibitors; kinase, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31311.18 |
Authors | Craven, G.B.,Wan, X.B.,Taunton, J. (deposition date: 2021-07-31, release date: 2022-06-08, Last modification date: 2023-11-29) |
Primary citation | Yang, T.,Cuesta, A.,Wan, X.,Craven, G.B.,Hirakawa, B.,Khamphavong, P.,May, J.R.,Kath, J.C.,Lapek Jr., J.D.,Niessen, S.,Burlingame, A.L.,Carelli, J.D.,Taunton, J. Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nat.Chem.Biol., 18:934-941, 2022 Cited by PubMed: 35590003DOI: 10.1038/s41589-022-01019-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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