7FEW

Pseudomonas aeruginosa Virulence Factor Regulator with cAMP ligand and auranofin gold analogues

7FEW の概要

• エントリーDOI: 10.2210/pdb7few/pdb
• 分子名称: cAMP-activated global transcriptional regulator Vfr, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: cyclic amp receptor protein, dna binding protein
• 由来する生物種: Pseudomonas aeruginosa PAO1; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49636.41

構造登録者

Chew, B.L.A.,Luo, D. (登録日: 2021-07-22, 公開日: 2022-07-27, 最終更新日: 2025-03-05)

主引用文献

Zhang, Y.,Chew, B.L.A.,Wang, J.,Yuan, M.,Yam, J.K.H.,Luo, D.,Yang, L.
Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr.
Comput Struct Biotechnol J, 21:2137-2146, 2023

PubMed Abstract: is a leading cause of hospital-acquired infections. Treatment of infections is difficult given its multiple virulence mechanisms, intrinsic antibiotic resistance mechanisms, and biofilm-forming ability. Auranofin, an approved oral gold compound for rheumatoid arthritis treatment, was recently reported to inhibit the growth of multiple bacterial species. Here, we identify 's global virulence factor regulator Vfr as one target of auranofin. We report the mechanistic insights into the inhibitory mechanism of auranofin and gold(I) analogues to Vfr through structural, biophysical, and phenotypic inhibition studies. This work suggests that auranofin and gold(I) analogues have potential to be developed as anti-virulence drugs against

PubMed: 37007650
DOI: 10.1016/j.csbj.2023.03.013

実験手法

X-RAY DIFFRACTION (1.75 Å)