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7FEH

Crystal structure of human DDR1 in complex with CH5541127

Summary for 7FEH
Entry DOI10.2210/pdb7feh/pdb
DescriptorEpithelial discoidin domain-containing receptor 1, N-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide, NITRATE ION, ... (4 entities in total)
Functional Keywordsreceptor tyrosine kinase, collagen, discoidin domain, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight36840.60
Authors
Fukami, T.A.,Kadono, S.,Matsuura, T. (deposition date: 2021-07-20, release date: 2022-07-27, Last modification date: 2024-05-29)
Primary citationKuhn, B.,Ritter, M.,Benz, J.,Kocer, B.,Sarie, J.C.,Hochstrasser, R.,Rudolph, M.G.,Kadono, S.,Matsuura, T.,Murata, T.,Richter, H.,Prunotto, M.
Novel potent and highly selective DDR1 inhibitors from integrated lead finding
Medicinal Chemistry Research, 32:1400-1425, 2023
Cited by
DOI: 10.1007/s00044-023-03066-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation

221051

数据于2024-06-12公开中

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