7FEH

Crystal structure of human DDR1 in complex with CH5541127

7FEH の概要

• エントリーDOI: 10.2210/pdb7feh/pdb
• 分子名称: Epithelial discoidin domain-containing receptor 1, N-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide, NITRATE ION, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, collagen, discoidin domain, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36840.60

構造登録者

Fukami, T.A.,Kadono, S.,Matsuura, T. (登録日: 2021-07-20, 公開日: 2022-07-27, 最終更新日: 2024-05-29)

• 主引用文献: Kuhn, B.,Ritter, M.,Benz, J.,Kocer, B.,Sarie, J.C.,Hochstrasser, R.,Rudolph, M.G.,Kadono, S.,Matsuura, T.,Murata, T.,Richter, H.,Prunotto, M.; Novel potent and highly selective DDR1 inhibitors from integrated lead finding; Medicinal Chemistry Research, 32:1400-1425, 2023; DOI: 10.1007/s00044-023-03066-2

実験手法

X-RAY DIFFRACTION (1.61 Å)