7FAZ

Crystal structure of the SARS-CoV-2 main protease in complex with Y180

Summary for 7FAZ

• Entry DOI: 10.2210/pdb7faz/pdb
• Descriptor: 3C-like proteinase, (2~{R})-~{N}-dibenzofuran-3-yl-~{N}-[(1~{R})-2-[[(1~{S})-1-(4-fluorophenyl)ethyl]amino]-2-oxidanylidene-1-pyridin-3-yl-ethyl]-2-oxidanyl-propanamide, SODIUM ION, ... (4 entities in total)
• Functional Keywords: coronavirus, protease, inhibitor, complex., viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 2
• Total formula weight: 68697.17

Authors

Zeng, R.,Quan, B.X.,Liu, X.L.,Lei, J. (deposition date: 2021-07-08, release date: 2021-07-21, Last modification date: 2023-11-29)

• Primary citation: Quan, B.X.,Shuai, H.,Xia, A.J.,Hou, Y.,Zeng, R.,Liu, X.L.,Lin, G.F.,Qiao, J.X.,Li, W.P.,Wang, F.L.,Wang, K.,Zhou, R.J.,Yuen, T.T.,Chen, M.X.,Yoon, C.,Wu, M.,Zhang, S.Y.,Huang, C.,Wang, Y.F.,Yang, W.,Tian, C.,Li, W.M.,Wei, Y.Q.,Yuen, K.Y.,Chan, J.F.,Lei, J.,Chu, H.,Yang, S.; An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.; Nat Microbiol, 7:716-725, 2022; PubMed: 35477751; DOI: 10.1038/s41564-022-01119-7

Experimental method

X-RAY DIFFRACTION (2.1 Å)