7FAN
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro
Summary for 7FAN
Entry DOI | 10.2210/pdb7fan/pdb |
Descriptor | Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (4 entities in total) |
Functional Keywords | inhibitor-bound structural comparison, translation, multi-drug |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 58538.93 |
Authors | Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (deposition date: 2021-07-06, release date: 2022-09-28, Last modification date: 2023-11-29) |
Primary citation | Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19:e1011124-e1011124, 2023 Cited by PubMed: 36854028DOI: 10.1371/journal.ppat.1011124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.769 Å) |
Structure validation
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