7FAN

Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro

7FAN の概要

• エントリーDOI: 10.2210/pdb7fan/pdb
• 分子名称: Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (4 entities in total)
• 機能のキーワード: inhibitor-bound structural comparison, translation, multi-drug
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58538.93

構造登録者

Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (登録日: 2021-07-06, 公開日: 2022-09-28, 最終更新日: 2023-11-29)

• 主引用文献: Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A.; Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.; Plos Pathog., 19:e1011124-e1011124, 2023; PubMed: 36854028; DOI: 10.1371/journal.ppat.1011124

実験手法

X-RAY DIFFRACTION (1.769 Å)