7FAJ
CARM1 bound with compound 43
Summary for 7FAJ
Entry DOI | 10.2210/pdb7faj/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine (3 entities in total) |
Functional Keywords | histone-arginine methyltransferase carm1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 154684.62 |
Authors | |
Primary citation | Zhang, Z.,Guo, Z.,Xu, X.,Cao, D.,Yang, H.,Li, Y.,Shi, Q.,Du, Z.,Guo, X.,Wang, X.,Chen, D.,Zhang, Y.,Chen, L.,Zhou, K.,Li, J.,Geng, M.,Huang, X.,Xiong, B. Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J.Med.Chem., 64:16650-16674, 2021 Cited by PubMed: 34781683DOI: 10.1021/acs.jmedchem.1c01308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24507255823 Å) |
Structure validation
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