7FAI

CARM1 bound with compound 9

7FAI の概要

• エントリーDOI: 10.2210/pdb7fai/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine (3 entities in total)
• 機能のキーワード: histone-arginine methyltransferase carm1, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 154716.70

構造登録者

Cao, D.Y.,Li, J.,Xiong, B. (登録日: 2021-07-06, 公開日: 2021-11-24, 最終更新日: 2023-11-29)

• 主引用文献: Zhang, Z.,Guo, Z.,Xu, X.,Cao, D.,Yang, H.,Li, Y.,Shi, Q.,Du, Z.,Guo, X.,Wang, X.,Chen, D.,Zhang, Y.,Chen, L.,Zhou, K.,Li, J.,Geng, M.,Huang, X.,Xiong, B.; Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.; J.Med.Chem., 64:16650-16674, 2021; PubMed: 34781683; DOI: 10.1021/acs.jmedchem.1c01308

実験手法

X-RAY DIFFRACTION (2.09749259173 Å)