7F9A
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97
7F9A の概要
エントリーDOI | 10.2210/pdb7f9a/pdb |
分子名称 | Bifunctional glutamate/proline--tRNA ligase, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ZINC ION, ... (7 entities in total) |
機能のキーワード | protein translation, inhibitor, prs, atp pocket, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 116884.96 |
構造登録者 | |
主引用文献 | Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19:e1011124-e1011124, 2023 Cited by PubMed: 36854028DOI: 10.1371/journal.ppat.1011124 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.999 Å) |
構造検証レポート
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